PISSN: EISSN: Green methods for
vast use of green chemistry in synthesis of heterocyclic compounds. Using grinding method Bose et al, 2004 reported the synthesis of ethyl 6methyl4phenyl2thioxo1,2,3,4tetrydropyrimidine5carboxylate (I) with grinding technique by using Biginelli reaction. This method is simple, easy workup and environmentally benign. NH N H H3C S O EtO (I)